![]() How Do We Use the Information That You Provide to Us?īroadly speaking, we use personal information for purposes of administering our business activities, providing service and support and making available other products and services to our customers and prospective customers.None of this information is associated with you as an individual. This information is collected on an aggregate basis. Information gathered through cookies and server logs may include the date and time of visits, the pages viewed, time spent at our website, and the sites visited just before and just after ours. Similar to other websites, our site may utilize a standard technology called "cookies" (see explanation below, "What Are Cookies?") and web server logs to collect information about how our website is used. We provide the same protections for these electronic communications that we employ in the maintenance of information received by mail and telephone. If you choose to correspond with us through email, we may retain the content of your email messages together with your email address and our responses. We may request that you voluntarily supply us with personal information, including your email address, postal address, home or work telephone number and other personal information for such purposes as correspondence, placing an order, requesting an estimate, or participating in online surveys. ![]() Personal Information You Choose to Provide.When you visit our website you may provide us with two types of information: personal information you knowingly choose to disclose that is collected on an individual basis and website use information collected on an aggregate basis as you and others browse our website.
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![]() OpenRoads Designer: This new breed of civil design tool combines mesh data with detail design in one dynamic environment.Ĭloud analytics: Knowledge is power Bentley is helping engineers ‘design out’ delays before they happen, by giving them access to real-time supply info. The age of the reality mesh: Bentley Systems is forging ahead with Reality Capture by embedding reality meshes into its foundation platform. This article is part of a Bentley Systems Year In Infrastructure special report. The big challenge for Bentley will be letting designers, engineers and architects know that it’s not just for Bentley customers. Now, with new VR capabilities, the software looks set to become an even more compelling tool for AEC professionals. We first saw LumenRT last year, and were hugely impressed by its quality, performance and ease of use. According to Bentley, as everything within the model is ‘instanced’, the memory footprint has been reduced dramatically, helping keep 3D performance levels high, even with large models. Once inside VR, ‘BIM hotspots’ will allow users to view the underlying BIM data simply by hovering over an object and clicking. The software can read in levels, layers, lights, animation paths and metadata. LumenRT doesn’t just bring across geometric data. ![]() Then, because the geometry is already optimised, moving into VR only takes a matter of seconds.įor distribution to clients and colleagues, projects can be packaged up as a ‘LiveCube’, a self-extracting executable. Getting CAD data into LumenRT only takes minutes to process, even with big scenes. Bentley says the workflow from CAD to VR is simple. In addition to MicroStation, AECOsim, SITEOPS and other Bentley tools, the software works with Revit, ArchiCAD, CityEngine and SketchUp. This decision was based on two factors: First, the ability of its engine to scale from small buildings to giant infrastructure projects, above and below ground, and second, the fact that it already had built-in tools for generating realistic AEC-specific features such as cars with wheels that move and traffic flows that are real, thanks to direct interfaces to MicroStation Traffic and VISSIM.ĬAD users outside of Bentley’s customer base will benefit, too. Three years in development, Bentley explored a whole range of VR game engines, such as Unreal and Unity, but decided to adapt its own engine instead. This will deliver a fully immersive, interactive experience where users can freely explore LumenRT’s 3D worlds populated with moving vehicles, animated characters and wind-blown skies. Things should get even more exciting next month when Bentley ships LumenRT Connect Edition Update 2, which will feature support for the Oculus Rift and HTC Vive. ![]() With Office 365 ProPlus teachers can take advantage of great Office apps and add-ins like Office Mix to record and publish class lectures. It also gives them access to all their Office documents both at school and at home. It will allow teachers to install full Office on up to five PCs or Macs and unlock the editing capabilities of the Office apps for iPad. This means that any organization purchasing Office for all of their faculty and staff can now include an Office 365 ProPlus subscription at no extra cost for all students, faculty and staff.Įxtending the Office 365 ProPlus benefit to faculty and staff ensures that teachers are using the latest versions of Office and the same feature set as their students. We have even more great news to share-we’re also announcing that faculty and staff will soon be able to access the same Office 365 ProPlus benefit as their students. Office 365 ProPlus benefit available for faculty and staff starting December 1, 2014 The new self-service model removes all of that unnecessary friction and delay by simply allowing eligible students to sign up for the service themselves, while maintaining the same level of control, flexibility and security institutions have come to expect from Office 365. ![]() All this needed to be done prior to students being able to access Office and OneDrive. In the past, organizations were required to initiate the service, create accounts and order the free licenses on behalf of their students. These changes not only make it easier for students to get Office, but it makes managing the services easier on school IT. You can see the new sign-up process on the Garage Series with host Jeremy Chapman as well as other really cool features of Office Mix, Power Map and OneNote. In order to be eligible for this benefit, the student must attend a school that has purchased Office organization-wide for all faculty/staff via the Microsoft Volume Licensing program. today, and will expand worldwide later this year. Sign-up for students is available in the U.S. Installation on up to five PCs or Macs, and Office apps on other mobile devices including Windows tablets and iPad.The latest versions of Microsoft Word, Excel, PowerPoint, OneNote, Outlook, Access and Publisher.Here’s what qualified students will receive: Enter a valid school-provided email address.If you’re a student 13 years-old of age or older, here’s what you can do the check your eligibility and get Office for free: Today we’re making it easier on the school IT department with a new self-serve model for students that lets them sign up for the free service on their own. One drawback to Student Advantage-the onus has been on the school to initiate the service, create an account and order the Office 365 license on behalf of the student. It was just about a year ago we announced Student Advantage, a benefit that allows eligible students to get Office 365 from their school for free. ![]() While the number of distal regions opening or closing in CMPs or GMPs compared with LT-HSCs were similar in the WT mice, substantially fewer distal regions were open in the Daxx-KO animals (Fig. Principal component analysis (PCA) showed separate clustering of WT and Daxx-KO samples (Extended Data Fig. Sorted LT-HSCs, common myeloid progenitors (CMPs) and granulocyte-monocyte progenitors (GMPs) from wild-type (WT Daxx +/+ RosaCre ERT2+/–) and Daxx-KO ( Daxx F/F RosaCre ERT2+/–) mice were processed 3 weeks post tamoxifen treatment/induction (w.p.i.) for transposase-accessible chromatin sequencing (ATAC-seq Fig. To assess the impact of Daxx loss on the chromatin landscape of haematopoietic stem and progenitor cells (HSPCs), we crossed a conditional Daxx-knockout (KO) line with Rosa26CreERT2 mice (Extended Data Fig. However, their impact on tissue homeostasis, inflammation and oncogenesis remains only partially understood.Įxpression of Daxx, Atrx and the other H3.3 chaperone Hira 17 during haematopoiesis is enriched in long-term haematopoietic stem cells (LT-HSCs), megakaryocyte-erythrocyte progenitors and B cells (Extended Data Fig. Notably, loss-of-function mutations in DNA methyltransferases, DAXX and ATRX are found in human cancer, including myeloid malignancies 12, 13, 14, 15, 16. ![]() Loss of ERV/RTE silencing may activate their enhancer function in embryonic stem cells 11. In embryonic stem cells, DNA methylation and incorporation of the histone 3.3 (H3.3) variant via the Death domain-associated protein (Daxx)–Alpha-thalassaemia X-linked mental retardation (Atrx) complex restricts accessibility to selected RTEs, such as intracisternal particles (IAPs) 9, 10. Given the pleiotropic roles of ERVs/RTEs and their potentially detrimental effects on cell and tissue homeostasis, several mechanisms are in place to regulate their accessibility and expression. Aberrant opening and/or expression of ERVs/RTEs has been linked to inflammageing, cancer and autoimmunity 4, 5, 6, 7, 8. ERVs and RTEs (ERVs/RTEs) have emerged as important regulators of key DNA- and RNA-based cellular functions, such as assembly of transcriptional networks, splicing and mutagenesis 1, 2, 3. Repeat elements, including endogenous retroviral elements (ERVs), retrotransposable elements (RTEs) and telomeric repeats, represent more than half of the human genome. Overall, our findings implicate retrotransposable element silencing in haematopoiesis and suggest a cross-talk between the H3.3 loading machinery and the pioneer transcription factor Pu.1. While these molecular and phenotypic perturbations are in part reverted in animals lacking both Pu.1 and Daxx, haematopoietic progenitors in these mice show unique chromatin and transcriptome alterations, suggesting an interaction between these two pathways. This causes neutrophilia and inflammation, predisposing mice to develop an autoinflammatory skin disease. Loss of Daxx alters the chromatin landscape, H3.3 distribution and histone marks of haematopoietic progenitors, leading to engagement of a Pu.1-dependent transcriptional programme for myelopoiesis at the expense of B-cell differentiation. Here we implicate the histone H3.3 chaperone Daxx, a retrotransposable element repressor inactivated in myeloid leukaemia and other neoplasms, in protection from inflammatory disease. However, the underlying mechanisms are only partially understood. Nature Cell Biology volume 23, pages 1224–1239 ( 2021) Cite this articleĭefective silencing of retrotransposable elements has been linked to inflammageing, cancer and autoimmune diseases. Aberrant chromatin landscape following loss of the H3.3 chaperone Daxx in haematopoietic precursors leads to Pu.1-mediated neutrophilia and inflammation Here we’re going to recommend you some of the best custom maps you can get for FS22 Farming Legend Just go on the website and pick your favourites from LS 22 best Map mods. Having mods not only makes your game more exciting but also can give you enormous advantages against your fellow players. If you want to become the best in the game, you need to start using mods. We can speak all we want, but it would be best for you to just begin and try them yourself, that way you will be able to check out all the best FS 22 best Maps features. If you use these LS22 Maps mods, you will be able to have a really great farming experience and make your game even more interesting with new lands or fields. The first step would be to go on our website and check out the database of our LS 22 best Maps. We already said multiple times that most of the players in the game use mods and if you still haven’t tried mods, you can just start right now. These Farming Simulator 22 maps mods are so beneficial for your game – if you haven’t yet tried them, you must! All the best players would agree with us – you have to try and use FS22 best Map mods because they make your game unique and allow you to play to all of your capabilities! Just follow our steps and download your mods now! We hope that our guidelines will give you an idea of which Farming Simulator 22 Maps mods to choose for your own game and our selection is the best there is in the market. ![]() Therefore, we want to give you all the information about the map mods. In addition to that, usually, all the newest FS22 mods also come out, so the community is very excited. If you are a big fan of Farming Simulator 22 for a while, you probably know that the new version is coming out already this year. ![]() ![]() What map can we expect on Farming Simulator 22 10 The Best Maps Mods for Farming Simulator 22 (All Free) See also: BDSM Gif for even more naughty fun. I hope you enjoyed our selections of hot and hard bondage gifs just for you ! They are the best and will make you cum before you even get to watch them all ! Don’t be shy, it’s an exciting world that adds another dimension to your sex life! Why not start by checking out our Threesome gif collection to whet your appetite? Unless you want to admire these splendid cumshot gif instead ? ![]() Submissive or dominant? Are you a fan of ropes, handcuffs, or maybe leather and ball gags? Here are 60 bondage gif to give you some inspiration, and to satisfy your depraved desires for sexual submission! Between submissive women, dominated men and sadomasochistic relationships, bondage often reveals some nice surprises.ĭid these bondage gif give you some fun ideas? Good, that’s what they’re there for! We hope that the possibilities these practices open up have inspired you, and that you’ll try them as soon as an opportunity comes up. To see more, visit our porn gif gallery, we have the hottest sex gif available. There is nothing quite like these naughty little games to awaken the bad boy in you, and to satisfy fantasies and desires that you didn’t even know you had! With these animated gifs, you’ll see a wide range of bondage practices, or when tying up or being tied up leads to an intense pleasure. Let’s explore this diversity with our selection of 60 bondage gif!īetween the artistic form of this practice widely considered as art in Japan (Shibari), and the sexual pleasures these practices can provide, it would be a shame not to take a deep dive into the world of bondage. Based on ropes, handcuffs, submission and domination, these sexual games provide a welcome diversity. It's time to elevate your bondage play and indulge in a new level of pleasure.Among the less common (but still incredibly pleasurable) sexual delights, are practices of bondage and shibari. Unleash your inner power, take control with this unique intimate tool. When not in use, store it in a cool, dry place to maintain its quality. The silicone mouthpiece can be cleaned with a toy cleaner or warm soapy water, and the leather strap can be wiped with a damp cloth. The leather strap, adjustable and durable, ensures a secure fit. Its smooth texture ensures a pleasant experience even in prolonged play. The mouthpiece, made from body-safe silicone, offers a soft but firm sensation against the skin. Comfort and Safety in QualityĬrafted from high-quality silicone and PU leather, this intimate accessory combines comfort and safety. This feature allows for a customizable level of fullness, catering to each partner's comfort level and the desired intensity of play. With a gentle squeeze of the attached bulb, the mouthpiece can be inflated to a girth of up to 3.74 inches. One of the most distinctive features of this product is its inflatable function. Each variant is designed to provide a unique sensory experience. All material in this publication is copyrighted V) by London Enterprises Limited and may not be. ![]() It is a quarterly publication of London Enterprises Limited and distributed by Lyndon Distributors Limited, 15756 Arminta Street, Van Nuys, California 91406. The bullet-shaped model measures 4.33 inches in length and 1.26 inches in diameter, while the penis-shaped one stretches up to 4.72 inches in length and 1.57 inches in diameter. BONDAGE PHOTO TREASURES NUMBER 18, JULY 1987 0343-L. This pleasure device boasts a unique and enticing shape, offering a choice between a bullet-shaped or a penis-shaped mouthpiece. Ignite the spark of dominance and let your partner surrender to your will. It's time to take your intimate games to the next level. Elevate your bondage sessions with this versatile tool. This commanding tool is a must-have for those seeking to explore the deeper realms of bondage play. The inflatable gag feature lets you take control, filling your partner's mouth to the brim as you desire. Its customizable fit offers the ultimate convenience, allowing you to adjust it to the perfect size for your partner. This innovative bondage accessory is not only a statement piece but also an instrument of submission. Experience a new level of control with this unique intimate tool. ![]() This double whammy poses problems for wheelchair travelers who need either a high or low bed. they can’t be lowered in any way) and there is no space underneath to place a hoist. Higher platform beds seems to be the new trend at US hotels, meaning that many beds are not adjustable (i.e. This is also why you will come across a wide range of bed heights and styles from hotel to hotel – even within the same chain, due to the fact that the majority of hotel properties are now franchised. This is why you will often find heavy and bulky furniture in wheelchair accessible rooms that are placed in a way that block access to the windows, outlets, nightstands, and thermostats. So, what happens when a wheelchair user travels and has to stay in a hotel room? It’s important to know that non-fixed furniture in US hotel rooms do not fall under the mandate of the Americans with Disabilities Act. Whoever designed this hotel room forgot I’d need access to the bed and blinds. A higher position also makes it easier for a caregiver to dress or reposition a wheelchair user who needs extra care, or for someone with knee or hip problems to get up out of bed. This often means there is more space under the bed to roll the supporting legs of a hoist or lift. For people like us, lower beds make it much easier for us to transfer safely and comfortable from our chairs to our beds.įor wheelchair users who require a considerable amount of care/assistance, a higher bed is likely better. Many manual wheelchair users have no lower body control, but have good upper body strength and can also self-transfer. I’m a power wheelchair user who can’t walk at all or lift my legs, but I can stand, plant my feet in one spot, and pivot to transfer. We’re able to customize our homes, and specifically our bedrooms, to meet our particular needs. That means that their daily living needs are totally different as well, which includes how they sleep. No two people with physical disabilities and/or the need for a wheelchair are the same. In this post, I take a look at the debate over the appropriate bed height in wheelchair accessible hotel rooms, the apparent lack of two-bed accessible rooms for families traveling with a wheelchair user, and what hotels can and can’t (or won’t) do to make things easier for wheelchair travelers. For travelers who use wheelchairs, however, a good night’s sleep in a hotel room – even one designated as wheelchair accessible – may be a pipe dream depending on a multitude of factors. Some people are more picky than others about the mattress type or pillows, but most just want to sleep. That’s all a traveler really wants when he or she arrives at a hotel room after a long day of travel. ![]() You cannot collect paper Canadian Tire Money on bonus offers. † In the form of electronic Canadian Tire Money® (CT Money®). Examples of borrowing costs (rounded to the nearest cent) assuming that all charges are purchases bearing interest at the regular annual rate of 21.99%, a 30 day month, no charges made on special payment plans and no other fees, additional payments or other changes are: The Triangle Mastercard and the Triangle World Elite Mastercard do not have an annual fee. The billing period covered by each statement can be from 28-33 days. ![]() For residents of Quebec, the period between the statement date and the due date for payment is 26 days. The minimum payment is the sum of (a) the greater of: (i) interest and fees shown on your statement + $10 or (ii) 5% of the New Balance, excluding amounts on special payment plans, (b) any balance over your credit limit, (c) any amounts past due not included in (b) above, and (d) the amount of any equal payments plan instalments then due. Some applicants may receive a higher or lower regular annual rate depending on a credit evaluation. Offer subject to change without notice.Īdditional information for residents of Quebec only: The regular annual rate for persons applying for the Triangle Mastercard and the Triangle World Elite Mastercard is 22.99% for cash transactions and related fees and 21.99% for all other charges. Any unpaid portion not received by the due date will no longer form part of the equal payments plan and interest will accrue on that amount from the day after the date of your next statement at the applicable regular annual rate. Each month during an equal payments plan you are required to pay in full by the due date that month’s equal payments plan instalment. There is no administration fee charged for entering into a special payments plan. ![]() However, if we do not receive the full minimum due on a statement within 59 days of the date of that statement, or any event of default (other than a payment default) occurs under your Cardmember Agreement, all special payment plans on your account will terminate and (i) you will then be charged interest on the balances outstanding on such plans at the applicable regular annual rate from the day after the date of your next statement, and (ii) the balances outstanding will form part of the balance due on that statement. Interest does not accrue during the period of the plan. Dealers may sell for less.įinancing available is “Equal payments, no interest” for 24 months (unless otherwise stated) and is only available on request, on approved credit and on purchases of $150 (unless otherwise stated) or more (Gift Cards excluded) made with your Triangle credit card at Canadian Tire, Sport Chek, Mark’s, L’Équipeur, Atmosphere, Sports Rousseau, Hockey Experts, L’Entrepôt du Hockey and participating Sports Experts. **Online prices and sale effective dates may differ from those in-store and may vary by region. ±Was price reflects the last national regular price this product was sold for. The tire producer / manufacturer and Canadian Tire uses this fee to pay for the collection, transportation, and processing of used tires.ĬANADIAN TIRE® and the CANADIAN TIRE Triangle Design are registered trade-marks of Canadian Tire Corporation, Limited. △The tire producer / manufacturer of the tires you are buying, and Canadian Tire is responsible for the recycling fee that is included in your invoice. ![]() Auto Typer to type automatically on Keyboard. Auto Clicker to keep mouse cursor clicking at current mouse curor location. Auto Mouse Click Software download to automate single / double left or right Mouse Clicks. The syntax files for these are stored in the Extras \ Editors directory of the AutoIt installation. Download Dual Monitor Software Utility to get better control of your dual or multiple monitors / display devices. If you don’t want to use SciTe or have your own favorite text editor then AutoIt comes with syntax files for the following editors “out of the box”: The homepage for the AutoIt version of SciTe can be found here. Syntax highlighting and code completion.The AutoIt team has created a custom version of SciTe that has the following features and tools included: Programming and writing scripts in Notepad can be a pain. Note: The beta can be unstable – always check the forums. Non-English documentation(Zipped).Documentation in various languages.ĪutoIt BETA.You can download the latest AutoIt beta and related files from here. v3.3.8.1 – Last version to support Windows 2000.v3.2.12.1 – Last version to support Windows 95 and Windows NT 4.0.Download the package below for the full version!ĪutoIt Script Editor.(Customised version of SciTE with lots of additional coding tools for AutoIt)ĪutoIt– Self Extracting Archive (for those who don’t like/want an installer)(includes x86 and 圆4 components and Aut2Exe and AutoItX)ĪutoIt Previous Versions – Here are some notable previous versions: Editor – A cut down version of the SciTE script editor package to get started.Add AutoIt features to your favorite programming and scripting languages! Also features a C# assembly and PowerShell CmdLets. Aut2Exe – Script to executable converter. ![]() ![]() AutoIt program files, documentation and examples.If you get a Microsoft SmartScreen warning after downloading the installer please see the SmartScreen and AutoIt page for more details. The AutoIt installer and executables have been digitally signed by AutoIt Consulting Ltd. Here you can download AutoIt and related files. Windows Vista and Windows Server 2008/2008 R2.You can download the main AutoIt package and other related scripting tools from this page. The current version of AutoIt has works on the following operating systems: ![]() This system is used to easily identify the correct size of a ring for a recipient. Ring sizes in the United Kingdom, Australia, New Zealand, South Africa and Ireland are designated by letters for both full and half sizes. The numerical scale for ring sizes in the United States ranges from 1 to 13, with a half size and quarter sizes available. Navigating International Ring Size Systemsĭifferent countries have their own ring sizing systems, which can create confusion when purchasing rings from international sellers or comparing sizes between different countries. Consider getting a free ring sizer from a jewelry store or online retailer to ensure accuracy.īy following these ring sizing tips, you can measure ring size accurately and find a ring that fits perfectly.Compare the measurement to a ring size chart to determine your ring size.Use a flexible measuring tape or a piece of string to measure the circumference of your finger.Measure your finger at the end of the day when it is warm and slightly swollen.Some tips for measuring your ring size accurately include: For optimal comfort, the ring should fit snugly on the finger, yet be able to slide over the knuckle with minimal effort. Furthermore, the fingers on the dominant hand are generally larger. It is recommended to measure one’s ring size at the end of the day when the fingers are warm, as finger size may vary depending on the time of day and the weather. To ensure a proper fit, it’s helpful to consult a men’s ring size chart. Getting the right ring size is important for comfort and to prevent the ring from slipping off or getting stuck on the finger. The average ring size for men is around 9-10, while for women, it is around 6-7. Half sizes are also available for a more precise fit. Ring sizes are represented numerically, corresponding to the inner circumference in millimeters. |
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